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Anal cancer is a cancer which arises from the anus , the distal opening of the gastrointestinal tract. Prevention includes avoiding risk factors and HPV vaccination. Symptoms of anal cancer can include pain or pressure in the anus or rectum, a change in bowel habits, a lump near the anus, rectal bleeding, itching or discharge. Bleeding may be severe. Most anal cancers are squamous cell carcinomas epidermoid carcinomas , that arises near the squamocolumnar junction. It may be keratinizing basaloid or non-keratinizing cloacogenic.
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Anal Disorders - Harvard Health

Anal cancer is a type of cancer that forms in tissues of the anus. The anus is the opening of the rectum to the outside of the body and at the end of the GI tract. Sometimes anal cancer causes no symptoms at all. But bleeding is often the first sign of the disease. The bleeding is usually minor. At first, most people assume the bleeding is caused by hemorrhoids painful, swollen veins in the anus and rectum that may bleed.
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A painful anal lesion

The anus is that part of the intestinal tract that passes through the muscular canal of the pelvis and anal sphincters. It is the final orifice through which stool passes out of the body. In adults, the anus is 4 to 5 centimeters long.
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Anal cancer is a disease in which cancer cells are present just inside or immediately outside the anus. Most cases of anal cancer are linked to human papillomavirus HPV , a very common infection that can be passed on during sex. Most adults have had HPV infection.
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